The most obvious are the game's secret rooms and super secret rooms. Some Helpful SecretsĪfterbirth+ has countless secrets that can provide players with helpful benefits to improve their run. However, one lesser known transformation is Bookworm, which can be earned by picking up three book items and allows the player to occasionally fire a double-shot. The most well known one is the Guppy transformation, which involves picking up three Guppy themed items. RELATED: Castlevania: Everything You Need to Know About Lament of Innocence/Curse of DarknessĪ different kind of synergy includes transformations. These often require the player to pick up a certain number of items out of a small pool of themed items. Due to Azazel's unique starting brimstone laser, most items that would normally synergize with Brimstone do not work or simply provide a damage upgrade.
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The previously mentioned Mom's Knife + Brimstone combination will work on any character except for Azazel. Some item synergies also depend on the character selected. Another good resource for learning item synergies is the Platinum God website, though this will spoil late-game items. There are mods on the workshop that provide details on how certain items work together. Some synergies also depend on the order that the player picks up the items. For example, picking up My Reflection and Ipecac will give the player exploding tears that arc back towards the player.
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However, not all item synergies are beneficial. Understanding what item synergies do is vital to completing some of the game's more difficult bosses. For example, picking up Brimstone and Mom's Knife will grant the player a brimstone stream made entirely out of knives. Synergies refer to how certain items can combine their effects to create stronger ones.